[HTML][HTML] Inhibition of caspase-2 translation by the mRNA binding protein HuR: a novel path of therapy resistance in colon carcinoma cells?
W Eberhardt, U Nasrullah, K Haeussler - Cells, 2019 - mdpi.com
… Moreover, caspase-2 is a target of alternative splicing which gives rise to two proteins with …
activity. Our previous finding that protein kinase C (PKC) triggered phosphorylation of different …
activity. Our previous finding that protein kinase C (PKC) triggered phosphorylation of different …
HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs
M Pabis, GM Popowicz, R Stehle… - Nucleic acids …, 2019 - academic.oup.com
… Full-length HuR with mutations that affect RRM3 RNA binding … role of RRM3 in RNA binding
and functional activity of HuR. … ), we propose that dimerization enables recognition of tandem …
and functional activity of HuR. … ), we propose that dimerization enables recognition of tandem …
Regulation of the SIRT1 signaling pathway in NMDA-induced Excitotoxicity
…, J Wu, J Ma, P Si, L Yin, Y Zhang, LJ Yan, C Zhang - Toxicology Letters, 2020 - Elsevier
… HuR is best known as a direct target of protein kinase C (PKC) … We examined PKC activity
using a PKC activity kit. In this … + -dependent PKC makes a major contribution to PKC activation …
using a PKC activity kit. In this … + -dependent PKC makes a major contribution to PKC activation …
[HTML][HTML] Identification of TRIM25 as a negative regulator of caspase-2 expression reveals a novel target for sensitizing colon carcinoma cells to intrinsic apoptosis
U Nasrullah, K Haeussler, A Biyanee, I Wittig… - Cells, 2019 - mdpi.com
… some well-known RNA-binding proteins, including HuR, we … in TRIM25-caspase-2 RNA
binding was found in total and in … act as a damage sensor, allowing cells to initiate apoptosis as …
binding was found in total and in … act as a damage sensor, allowing cells to initiate apoptosis as …
HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs
SM García Mauriño, M Pabis, GM Popowicz… - Nucleic Acids Research …, 2019 - idus.us.es
… Our results reveal an important role of RRM3 in RNA binding and functional activity of HuR…
Domain-specific phosphomimetic mutation allows dissection of different protein kinase C (PKC…
Domain-specific phosphomimetic mutation allows dissection of different protein kinase C (PKC…
[HTML][HTML] The E3 Ligase TRIM25 Impairs Apoptotic Cell Death in Colon Carcinoma Cells via Destabilization of Caspase-7 mRNA: A Possible Role of hnRNPH1
… is involved in caspase-7 mRNA binding, we, in addition to the … , which allow the capturing
of ubiquitinated proteins with high … mRNA binding, indicating that the ubiquitin ligase activity is …
of ubiquitinated proteins with high … mRNA binding, indicating that the ubiquitin ligase activity is …
[HTML][HTML] Regulation of DNA damage response and homologous recombination repair by microRNA in human cells exposed to ionizing radiation
M Szatkowska, R Krupa - Cancers, 2020 - mdpi.com
… in the mitogen-activated protein kinase (MAPK) and WNT … modification, which allows other
DDR protein components to be … The activity of HR involves resection at the DSB and repair …
DDR protein components to be … The activity of HR involves resection at the DSB and repair …